Catechin and other catechol-containing secondary metabolites: Bacterial biotransformation and regulation of carbohydrate metabolism

Catechol, 1,2-dihydroxybenzene, prepared through bacterial biotransformation from higher order polyphenols, has been proposed to regulate carbohydrate metabolism, especially in the context of type 2 diabetes. This review aims contextualize this finding. It describes biosynthesis catechol both glucose, and as a degradation product natural products transformation. The then considers mechanism action glycemic-regulating catechol-containing materials complications arising balancing their inherent activity with that catechol, common product. enumerates potential dietary sources catechin foods. Articles were found using combination key word searches Pubmed, Web Science, Scifinder, coupled following relevant references those articles, tracking articles cite them. is not systematic review, so only germane specific needs included. Catechol potentially promising metabolite for modulating but themselves mediate glucose homeostasis number competing mechanisms. levels catechins quite low most foods exception cocoa, chicory, green tea. Catechin-rich tea might prove useful supplement work catechol-producing probiotic; however, further studies are required determine physiological relevance approach.